Designing the Future of Medicine
International Collaborations
Genome Science and Network Biology: Personalized Medicine

Personal Genome Architecture (PGA)

The mission of the CBS.GenNetMed is to contribute in the emerging innovative international effort to translate genome architecture-based information into clinical personalized healthcare. Breakthroughs in high-throughput (HT) technologies and dramatic advances in genome sciences and dynamic network biology revolutionize medicine. The epoch of clinical network genomic medicine marks this century.

Clinical cancer genome

In cancer, sophisticated integrated genome analysis obtained from a patient's cancer-normal pair tissue and blood samples followed by advanced bioinformatics provides now a fascinating individualized genome-wide molecular characterization of cancer. An individual patient's tumor comprehensive genome analysis of both whole-genome mutational landscape and dynamic genome dysfunction enabling prediction of gene expression, intracellular signaling pathways network and cell-cell communication can be related with clinical data and phenotypes such as clinical outcome and response to therapeutics. This crucial for the clinic understanding of whole genome-phenotype map is now revolutionizing biomedical research arena for the discovery of next-generation biomarkers and druggable targets.
High-throughput technologies
•  Deep sequencing
•  Integrated genome analysis
Clinical data, biological samples
Linking genome architecture changes with disease phenotype
Biomarkers - tailoring the best combinations of available drugs
Novel therapeutic targets disrupting cancer cells' biocircuits


ISSN : 1109 - 7647
   Print ISSN : 1109 - 7655


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last update: 12 December 2012