Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer
DOI: 10.2122/gbc.2002.0015

October, 2002

Risks and Benefits of Risk-Reducing Surgery in Inherited Breast and Gastric Cancer Susceptibility


Prophylactic risk-reducing surgery has been earlier suggested effective to improve survival in individuals selected on the basis of a strong family history. Now, genetic testing has increased the accuracy of cancer risk estimates and allows surgery to target CDH1 or BRCA mutation carriers who are at in fact high risk of developing gastric cancer and breast cancer respectively. Here, we discuss the reinvigorated role of prophylactic surgery in the management of hereditary diffuse gastric cancer and breast cancer syndromes..

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Online ISSN : 1109 - 7647
   Print ISSN : 1109 - 7655

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last update: 22 May 2003