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TOP 10 Cancer Precision Medicine (CPM) papers in 2019
* The selection was based on:
1. Validity of data
2. Innovation
3. Potential fast translation into the clinic.
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1. Sabarinathan R, Pich O, Martincorena I, et al. The PCAWG Drivers and Functional Interpretation Group and the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network. The whole-genome panorama of cancer drivers.
This pre-print on the PCAWG Consortium will be published in Nature, 2020. |
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2. Wan N, Weinberg D, Liu TY, et al. Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA. BMC Cancer. 2019 Aug 23;19(1):832. doi: 10.1186/s12885-019-6003-8.
This is a pre-print in BioRxiv. |
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3. Wang H, Nakamura M, Abbott TR, et al. CRISPR-mediated live imaging of genome editing and transcription. Science. 2019 Sep 20;365(6459):1301-1305. doi: 10.1126/science.aax7852. |
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4. Demircioglu D, Cukuroglu E, Kindermans MA, et al. Pan-cancer Transcriptome Analysis Reveals Pervasive Regulation through Alternative Promoters. Cell. 2019 Sep 5;178(6):1465-1477.e17. doi: 10.1016/j.cell.2019.08.018. |
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5. PCAWG Transcriptome Core Group; Calabrese C, Davidson NR, Fonseca1 NA, et al. Genomic basis for RNA alterations revealed by whole-genome analyses of 27 cancer types.
This pre-print on the PCAWG Consortium will be published in Nature, 2020. |
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6. Porteus MH. A New Class of Medicines through DNA Editing. N Engl J Med. 2019 Mar 7;380(10):947-959. doi: 10.1056/NEJMra1800729.
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7. Ligorio M, Sil S, Malagon-Lopez J, Nieman LT, et al. Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer. Cell. 2019 Jun 27;178(1):160-175.e27. doi: 10.1016/j.cell.2019.05.012. |
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8. Kyrochristos ID, Roukos DH. Comprehensive intra-individual genomic and transcriptional heterogeneity: Evidence-based Colorectal Cancer Precision Medicine. Cancer Treat Rev. 2019 Nov;80:101894. doi: 10.1016/j.ctrv.2019.101894. |
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9. Kyrochristos ID, Ziogas DE, Roukos DH. Dynamic genome and transcriptional network?based biomarkers and drugs: precision in breast cancer therapy. Med Res Rev. 2019 May;39(3):1205-1227. doi: 10.1002/med.21549. |
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10. Kyrochristos ID, Ziogas DE, Roukos DH. Drug resistance: origins, evolution and characterization of genomic clones and the tumor ecosystem to optimize precise individualized therapy. Drug Discov Today. 2019 Jun;24(6):1281-1294. doi: 10.1016/j.drudis.2019.04.008. |
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