Current
best practices and rationalistic perspectives in causation-based
prevention, early detection and multidisciplinary treatment
of breast and gastric cancer
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REVIEW |
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| P27Kip1
and Gastric Carcinoma George K Anagnostopoulos MD1, Dimitrios Stefanou MD PhD, Niki J Agnantis MD PhD FRCPath[2] |
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Abstract |
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| P27Kip1,
a cyclin-dependent kinase inhibitor, plays an important role as
inhibiting the progression of the cell cycle. Decreased expression
of P27Kip1
is associated with high histological grade and aggressiveness
of several tumors. Loss of P27Kip1
occurs early during carcinogenesis. Recently, subcellular cytoplasmic
localization has also been proposed as a regulatory mechanism
of P27Kip1
function. This study reviews all current information about the
functions and regulation of p27, its deregulation during gastric
carcinogenesis, and summarizes all evidence existing in the literature
on the immunoexpression of P27Kip1
in gastric cancer.
Key words: p27, gastric cancer, Helicobacter pylori, prognosis |
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