Current
best practices and rationalistic perspectives in causation-based
prevention, early detection and multidisciplinary treatment
of breast and gastric cancer
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Gastric
& Breast Cancer e-journal
DOI: 10.2122/gbc.2006.0048
MINI
REVIEW
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Overexpression
of Erbb2 in Breast Cancer: Associated Signal Transduction and
Termination Events
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G.
Chandra Sekhar Babu, MSc[1,2], M Laxmi Narasu, PhD[1] and P Ajay
Babu, MSc, MTech[2]* |
ABSTRACT |
Human
epidermal growth factor receptor 2 (HER2 or ErbB2), is a member
of subclass I of the superfamily of receptor tyrosine kinases.
It has a vital role in breast cancer. Overexpression or amplification
of ErbB2 is observed in many breast cancer patients, in whom,
normal cells turn out to be cancerous, and lead to poor prognosis.
ErbB2 receptor protein is involved in the activation of several
signal transduction events: Ras-MAPK, IP3/DAG, PI3-K and JAK/STAT
pathways, respectively. In this review, the role of ErbB2 in
breast cancer is discussed and the current status of the related
ErbB2 receptor pathways induced by overexpression and signal
termination events are presented.
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