Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2010.0139


Biomarkers for personalizing health: concerns, challenges and prospects

George Zografos M.D, PhD.

Affiliation: Head of the Breast Unit, Head of 1st Department of Propaedeutic Surgery, University of Athens, Greece.

Tel: +306932524836



The urgent need for developing markers to predict therapeutic response, adverse effects, and prognosis in individual patients has resulted in an explosion in biomarkers translational research and papers. But the impact of this huge effort in medical practice is still modest. Valid concerns raise the absence of robust methodology currently used. Here it is discussed how despite rapid developments in genetic and epigenetic basis of major complex diseases such as cancer, diabetes and other disorders, the way to understand complex genetic regulation and cellular homeostasis is long and full of challenges. But latest technological advances permitting a massively parallel monitoring of multiple biomolecules and in functional genomics shape now high hope for a comprehensive view of functional organization. By improving our understanding of structural and functional regulation of human genome, the discover of robust biomarkers will become realistic for personalized medicine.

(Citation: Gastric & Breast Cancer 2010; 9(4): 157-162)

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Online ISSN : 1109 - 7647
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last update: 24 November 2010