ABSTRACT

The urgent need for developing markers to predict therapeutic response, adverse effects, and prognosis in individual patients has resulted in an explosion in biomarkers translational research and papers. But the impact of this huge effort in medical practice is still modest. Valid concerns raise the absence of robust methodology currently used. Here it is discussed how despite rapid developments in genetic and epigenetic basis of major complex diseases such as cancer, diabetes and other disorders, the way to understand complex genetic regulation and cellular homeostasis is long and full of challenges. But latest technological advances permitting a massively parallel monitoring of multiple biomolecules and in functional genomics shape now high hope for a comprehensive view of functional organization. By improving our understanding of structural and functional regulation of human genome, the discover of robust biomarkers will become realistic for personalized medicine.

(Citation: Gastric & Breast Cancer 2010; 9(4): 157-162)

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