Millions of genetic variants and epigenetic events across human genome and epigenome having being accumulating over the evolutionary history ensure humans diversity. Each human being and each patient is unique. How can we understand this diversity, precondition to achieve personalized medicine?
Genetic variation is vital for the maintenance and continuation of species and life. But in a small proportion, DNA changes escape normal healthy fate, leading to major disorders such as cancer, cardiovascular and other deadly or chronic diseases. It is the wonder of nature that mutations-causing common deadly diseases, such as BRCA variants leading to hereditary breast cancer, are remaining very rare during evolution protecting life obliteration.
Identification of the whole set of genetic and epigenetic changes underlying common complex diseases appears a feasible future goal due to next-generation sequencing (NGS) technology.
But beyond structural basis, understanding functional organization of human life represents the biggest daunting challenge to unravel.
Here I discuss potential multidisciplinary strategies from mathematics to biomedical science to approach structural and functional background of health and disease. These research direction is focused on how to understand genetic regulation and gene expression due regulators of cancer networks such as for example miRNAs and transcriptomes. Predictions of inferences of nonlinear, complex, dynamic biomolecules and bioenvironmental networks are also described. If the functional basis of human life would ever be explored with scientific measurements, then personalize medicine could be achieved in a day-to-day clinical practice.
(Citation: Gastric & Breast Cancer 2010
Oct ; 9(4):
includes 3 figures 2 tables and 2 boxes.