Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2011.0183
COMMENTARY
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Laparoscopic Total Gastrectomy: Preventing Gastric Cancer in CDH1 Mutation Carriers. |
Prof. Andreas Sendler, MD, PhD
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Affiliation: Direktor der Chirurgischen Universitatsklinik, Marienhospital Herne Klinikum der Ruhr-Universitat Bochum, Holkeskampring 40, 44625, Herne, Germany.
E-mail : Andreas.Sendler@ruhr-uni-bochum.de |
Since there is no abstract available we provide the first paragraph
Asymptomatic persons with positive genetic testing for a causal inherited mutation in the CDH1 gene face both an over 90% probability to have foci of diffuse gastric cancer and a ~75% lifetime risk of developing hereditary diffuse gastric cancer (HDGC) syndrome [1]. These two arguments and improved short-term with minimally invasive surgery may convince young CDH1 mutation carriers to undergo prophylactic laparoscopic total gastrectomy (LTG).
(Citation: Gastric & Breast Cancer 2011; 10(3): 178-179)
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