Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2011.0183


Laparoscopic Total Gastrectomy: Preventing Gastric Cancer in CDH1 Mutation Carriers.

Prof. Andreas Sendler, MD, PhD

Affiliation: Direktor der Chirurgischen Universitatsklinik, Marienhospital Herne Klinikum der Ruhr-Universitat Bochum, Holkeskampring 40, 44625, Herne, Germany.

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Since there is no abstract available we provide the first paragraph

Asymptomatic persons with positive genetic testing for a causal inherited mutation in the CDH1 gene face both an over 90% probability to have foci of diffuse gastric cancer and a ~75% lifetime risk of developing hereditary diffuse gastric cancer (HDGC) syndrome [1]. These two arguments and improved short-term with minimally invasive surgery may convince young CDH1 mutation carriers to undergo prophylactic laparoscopic total gastrectomy (LTG).

(Citation: Gastric & Breast Cancer 2011; 10(3): 178-179)

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Online ISSN : 1109 - 7647
Print ISSN : 1109 - 7655

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last update: 29 June 2011