Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2012.0205


From whole-genome sequencing to gene expression regulation: Perspectives for improving oncological outcomes.

Dimitrios H. Roukos, MD, PhD.

Affiliation: 1 Personalized Cancer Genomics Medicine, Ioannina University School of Medicine, Ioannina, 45110 Greece.
2 Department of Surgery, Ioannina University School of Medicine, Ioannina, 45110 Greece.

T: +302651007423, F: +302651007094


Next-generation sequencing (NGS) has revolutionized biomedical research. The NGS platforms for whole-genome and exome sequencing, epigenome and transcriptome sequencing provide unprecedented ability for deeper insights into structure and function of cells genomes in healthy and cancer. Here, I discuss challenges and perspectives of fascinating research for identifying mutations (SNPs, insertions, deletions, copy-number alterations, translocations) and understanding functional regulatory circuits driving gene expression. Applications of all these NGS-based advances into targeted therapy, such as PLX4032 ( vemurafenib) for the treatment of melanoma patients with V600E mutation in the BRAF gene, and hope for improving survival are also summarized.

(Citation: Gastric & Breast Cancer 2012; 11(1): 1-6)

This article is 6 pages long.


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Online ISSN : 1109 - 7647
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last update: 18 December 2011