Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2012.0233


100 breast cancer genome sequencing: Heterogeneity-based diagnostic and therapeutic perspectives.

Chee-Seng Ku, MD, PhD.

Affiliation: Chee-Seng Ku, Cancer Science Institute of Singapore, National University of Singapore, Singapore.


Genes and mutations involved in breast cancer vary considerable reveals a latest study published in Nature [1]. Applying whole-exome sequencing in primary and metastatic tumors from 100 breast cancer patients, Stephens and colleagues [1] found 73 different combinations of cancer genes. This study reveals a wide genetic heterogeneity and nearly a specific for each patient mutational landscape. What are the consequences of this report on the clinic? How many driver mutations are required for transforming a normal cell to cancer cell? Can this WES-based testing lead to personalized therapeutics?

(Citation: Gastric & Breast Cancer 2012; 11(3): 127-130)

You can have an online full-text access and a PDF of this article:
  • Either purchase this paper for €35 EUR. Please, click here
Please specify DOI of article
  • Or through one year subscription PayPal

Online ISSN : 1109 - 7647
Print ISSN : 1109 - 7655

We subscribe to the HONcode principles of the HON Foundation. Click to verify. We subscribe to the HONcode principles. Verify here.
please, read our policy about privacy and confidentiality of information and transparency of sponsorship

last update: 4 July 2012