Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2012.0233
EDITORIAL
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100 breast cancer genome sequencing: Heterogeneity-based diagnostic and therapeutic perspectives. |
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Affiliation: Chee-Seng Ku, Cancer Science Institute of Singapore, National University of Singapore, Singapore.
E-mail: csikcs@nus.edu.sg |
Abstract
Genes and mutations involved in breast cancer vary considerable reveals a latest study published in Nature [1]. Applying whole-exome sequencing in primary and metastatic tumors from 100 breast cancer patients, Stephens and colleagues [1] found 73 different combinations of cancer genes. This study reveals a wide genetic heterogeneity and nearly a specific for each patient mutational landscape. What are the consequences of this report on the clinic? How many driver mutations are required for transforming a normal cell to cancer cell? Can this WES-based testing lead to personalized therapeutics?
(Citation: Gastric & Breast Cancer 2012; 11(3): 127-130)
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Online
ISSN : 1109 - 7647
Print ISSN : 1109 - 7655
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