Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2012.0245


Cellular signaling networks exploration for clinical applications.

Dimosthenis Ziogas, MD, PhD.

Affiliation: Dimosthenis Ziogas MD, PhD, Dept. of Surgery, University of Ioannina, School of Medicine, 45110 Ioannina, Greece.


Understanding and predicting signaling pathways is a top research priority by pharmaceutical industry and academia. This because behavior, response to stress, regulation and function of human cells and organs they form is orchestrated by signal transduction. Normal and healthy function of cells and organs is ensured by cell-cell connectivity and by a much more complex dynamic of biochemical intracellular signals transmission through a network of cooperative interactions, which include protein-protein gene-gene, DNA-proteins and other molecules interactions. Here the advances in pathways analysis and multiple challenges understanding how genetic and epigenetic alterations modify transcriptional activity, chromatin modeling and expression of multiple interacting genes leading to deregulation of signaling networks and diseases are discussed.

(Citation: Gastric & Breast Cancer 2012; 11(4): 221-225)



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last update: 30 October 2012