Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2017.0256

Mini Review

Therapeutic intervention of Hepatic, Billiary and Pancreatic cancer genomes in time and space.

George Glantzounis, MD, PhD.

Affiliation: George Glantzounis, Associate Professor of Surgery, Department of Surgery, University Hospital of Ioannina, Ioannina, TK 45110, Greece.


Spatiotemporal evolution of Hepatic, Billiary and Pancreatic (HBP) cancers, which represent a major health problem because of their high incidence, metastatic potential and mortality rates [1] could explain extremely complex molecular and mutational landscapes underlying therapeutic resistance and disease relapse. Over the past few years innovative but quite small studies exploring intratumor heterogeneity and circulating genomic subclones provide high expectations to predict and overcome intrinsic and acquired therapeutic resistance [2]. In this article, pioneering solutions to overcome major challenges in effective and sustainable therapeutic interventions are discussed.

(Citation: Gastric & Breast Cancer 2017; 12(1): 13-19)



You can have an online full-text access and a PDF of this article:
  • Either purchase this paper for €35 EUR. Please, click here
Please specify DOI of article
  • Or through one year subscription PayPal

Online ISSN : 1109 - 7647
   Print ISSN : 1109 - 7655

We subscribe to the HONcode principles of the HON Foundation. Click to verify. We subscribe to the HONcode principles. Verify here.
please, read our policy about privacy and confidentiality of information and transparency of sponsorship

last update: 25 February 2017