Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2017.0264


Predicting risk  of disease and therapeutic resistance for patients with Hepatocellular Carcinoma.

Demosthenes Ziogas, MD, PhD 1, 2.

Affiliation: Demosthenes Ziogas MD, PhD,
1Department of Surgery, 'G. Hatzikosta' General Hospital, Ioannina 45001, Greece
2Centre for Biosystems and Synthetic Genomic Network Medicine Center – CBS.GenNetMed Ioannina University, Ioannina, Greece.


Multiple negative phase II randomized controlled trials (RCTs) fail to prove a significant overall survival on evaluating the new targeted drugs and do not gain FDA approval. Conventional drug discovery strategy is associated with high costs of millions US dollars for pharmaceutical industry, adverse of patients in these trials receiving the experimental agent and lose long time for ineffective research towards an error of investigational direction.
In contrast to Biankin et al. in which drug effective prediction strategy has included both no biomarker and biomarker-directed agent, this opinion article is focused only on biomarker-directed drug development. This new concept can allow higher predictivity of the expected agent. Moreover, our concept is also focused on drug development based rational prospective clinico-genomic trials for the discovery of novel therapeutic targets.

(Citation: Gastric & Breast Cancer 2017; 12(2): 91-98)



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last update: 31 August 2017