Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2019.0285
REVIEW
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Spatiotemporal genome and transcriptome analyses enhances the development of new therapeutic targets for solid tumors.
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Prof. Dr. A. Sendler MD, PhD.
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Abstract
Although the development and approval of targeted drugs for metastatic tumors is rapidly increasing the establishment of these agents, with a few exceptions, has failed in the adjuvant or neo-adjuvant setting. The discovery of valid cancer driver genes and druggable mutations through recent recommendations on genomic and transcriptomic studies as well as clinical trials realized the necessity to overcome the recent evidence of interpatient and intrapatient for genetic, genomic and transcriptional heterogeneity. This review discusses the potential and challenges to improve the current poor oncological outcomes of major cancer types.
(Citation: Gastric & Breast Cancer 2019; 14(1): 73-82)
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