Gastrointestinal stromal tumors (GISTs) are rare neoplasms of the gastrointestinal (GI) tract which are associated with high rates of malignant transformation. The current study aims to design a survey to assess the incidence of GISTs in Iran through a multicenter population-based cancer registry study.
Materials and Methods
A total of 447 GISTs patients who have been registered to Iran National Cancer Registry (INCR) between 2009 to 2014 were ordered into age strata, based on WHO guidelines. Patients were categorized into six groups by region. Tumors were classified into GI and extra GI tumors. Also, grading of tumors performed according to the International Classification of Diseases for Oncology, 3rd Revision (ICD-O). Crude incidence rate, age-standardized incidence rate (ASIR), and sex standardized incidence rate (SSIR) were calculated by using SPSS software.
In the current study all 447 cases of GISTs that were registered between 2009 to 2014 were included. 56.5% of them (253/447) were male, with a male to female ratio of 1.3:1. The majority of patients were found in Isfahan (17.8%). 68.6% (307/447) of cases aged between 15 and 64, with the most involved age stratum being 50-55 years old (14.5%). Crude incidence rate was 5.948 per 1,000,000 and age standard incidence rate (ASIR) was 7.334 per 1,000,000. The highest ASIR was 1.593 per 1,000,000 in 2012 and then it declined. The stomach was the leading location of tumors (46%), followed by the small intestine (23%).
The occurrence of GISTs is more common in men and the older population. As a preliminary National Population study, the rate of GISTs in the Iranian population has been declined over the study period.
Keywords:Gastrointestinal stromal tumor, Incidence, Population-Based Study, gastric cancer.
(Citation: Gastric & Breast Cancer 2020; 15(1): 1-11)