Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2021.0307

FOCUS ARTICLE

Genome and transcriptome – based drug discovery and clinical predictors for meaningful  cancer treatment.

Chatterjee S, MD, PhD.

 

Abstract
Treatment guidelines modern oncology has improved oncological outcomes of cancer patients, but intrinsic and acquired drug resistance and relapse rates remain disappointingly high [1,2].  Future estimates suggest increase on incidence, late diagnosis and mortality rates if current conventional research and clinical practice will be continued [3]. Recent whole genome and transcriptome next generation sequencing of bulk samples as well as single cell genomics and transcriptomics have unraveled extensive intratumor heterogeneity and discovery of multiple drug targets. Tumor region-to-region and cell-to-cell heterogeneity-guided drug sensitivity as well as complex cancer-immune cell interactions shape the new era of precision oncology [4-6]. In this focus article clinical predictive biomarkers to guide tailored multi-drug therapy is discussed. [7-9].

(Citation: Gastric & Breast Cancer 2021; 16(1): 64-71)

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Print ISSN : 1109 - 7655

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last update: 1 January 2021