The first entirely sequenced genome for cancer patients is here ( Nature 2008; 456: : 66 ). Most recent sequencing studies analyzing about 20,000 genes in several common solid cancers (Cancer Genome Atlas) showed that in average 60 to 100 genetic alterations are involved in tumorigenesis ( Science 2007: 318:1108 and 2008; 321:1801). Most recently, Genome-wide association (GWA) studies published in Nature, Sciences and N Engl J Med identifying a tremendous number of novel genetic alterations in known or novel loci in common diseases including cancer confirm the theory: solid cancer are highly heterogeneous. This fact meets the plausible explanation of targeted agents, which target a single gene-encoded protein.