Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2009.0097
PERSPECTIVE
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H. pylori-diet and genetic factors interactions: Quantitative genetics gastric cancer targeted screening and prevention
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Dimosthenis Ziogas, MD |
| Affiliation: Dimosthenis Ziogas M.D., Surgical Oncology Research Unit, Dept of Surgery, University of Ioannina, School of Medicine, 45110 Ioannina, Greece.
E-mail: deziogas@hotmail.com
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Abstract
Globally, mortality from gastric cancer is a major health problem. Mortality rates in advanced stages of the disease remain disappointingly very high, particularly in the Western world. Despite improvements in surgical and adjuvant treatment, overall prognosis remains poor.
New conceptual approaches, basic sciences data accumulating, and statistics, indicate that cure rates can better and faster be improved if research and funding are focused more on the development of primary prevention, targeted screening of the population and treatment of patients detected at early stages of the disease.
In this perspective article is described how progress with genome-wide associations studies and development of causal networks to predict gene-gene and gene-H. Pylori/diet might lead to risk stratification-based prevention of gastric cancer.
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Online
ISSN : 1109 - 7647
Print ISSN : 1109 - 7655
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