MINI-REVIEW

Gastric Cancer Causation

Niki J. Agnantis, MD and Dimitrios H.Roukos, MD
From the Departments of Pathology (NJA) and Surgery (DHR), Ioannina University School of Medicine, 45110 Ioannina, Greece, droukos@cc.uoi.gr

Gastric cancer is the end result of a multifactorial, multigenetic, multistep process. Environmental exposures and genetic factors have been reported to cause gastric cancer but the debate about whether environment or heritability plays the principal role continuous. The knowledge of factors that influence gastric carcinogenesis is determinant for the development of strategies effective for prevention and treatment.

Over the past decades various conditions and risk factors have been identified to predispose to cancer development. However, now most clinical and research attention has been focused on Helicobacter pylori infection, the preneoplastic lesions chronic atrophic gastritis and intestinal metaplasia, the free-radicals and on familial gastric cancer predisposition.

http://www.gastricbreastcancer.com/grade_day_date.asp

http://www.gastricbreastcancer.com/grade_cellini.asp

http://www.gastricbreastcancer.com/grade_deville.asp