Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2006.0042


First randomized evidence for the superiority of extended over limited lymphadenectomy in gastric cancer: A never end debate.
Thedore Liakakos, Michael Fatouros, Dimosthenis Ziogas and Dimitrios H. Roukos
As this article has no abstract we provide the first paragraph.

For the first time, evidence is provided by a randomized controlled trial that extensive (D3) vs. limited (D1) surgery significantly improves overall survival. But However, the difference in recurrence-free survival between the two groups was not statistically significant. This paradox and a number of study weakness arises the following questions:

  • Are the results of this trial conclusive?
  • Is there an end in the long-term debate about the benefit of extended lymphadenectomy?
  • Do we need new randomized trials?
  • Until then what extent of lymphadenectomy can be considered as optimal?

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Online ISSN : 1109 - 7647
   Print ISSN : 1109 - 7655

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last update: 3 February 2004