Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer
DOI: 10.2122/gbc.2003.0020

May 2003

Cyclin E: A New Biologic Prognostic Marker
Cyclin E, a regulator of the cell cycle, affects the behavior of breast-cancer cells. A recent retrospective study of 395 patients with breast cancer shows that overexpression of cyclin E and low-molecular-weight isoforms of cyclin E in tumor issue, as measured by Western blot assay, is a stronger predictor of poor survival than the currently used predictors, as node-positive cancer, negative estrogen-receptor status and late stage of disease (N Engl J Med 2002 Nov).
This fascinating finding may have important clinical implications, but validation by prospective evaluation and much work is needed before low-molecular-weight and total cyclin E can be considered as relevant biomarkers which can be used into clinical practice.

Online ISSN : 1109 - 7647
   Print ISSN : 1109 - 7655

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last update: 22 May 2003