Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer
DOI: 10.2122/gbc.2003.0021

May 2003

Breast-conserving Treatment
Rational, Current Reality & Limitations


Recently published 20-years follow-up scientific data confirm that there is no difference in survival after breast conservation therapy or total mastectomy in women with stage I or II breast cancer. However, breast conservation treatment is associated with an increased risk of both positive margins and local recurrence. Current estimates suggest that 10 to 20% of women after breast-conserving treatment is at high-risk of local failures. This is a characteristic example of limitations and lack of generalizability of randomized controlled trials, which are the gold standard for treatment decision-making.

Can the women at high-risk of local failure be identified and how can we minimize the risk of local failures?


Online ISSN : 1109 - 7647
   Print ISSN : 1109 - 7655

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last update: 22 May 2003