Current
best practices and rationalistic perspectives in causation-based
prevention, early detection and multidisciplinary treatment
of breast and gastric cancer
|
PERSPECTIVE |
Cyclin
E: A New Biologic Prognostic Marker |
| Abstract |
| Cyclin
E, a regulator of the cell cycle, affects the behavior of breast-cancer
cells. A recent retrospective study of 395 patients with breast
cancer shows that overexpression of cyclin E and low-molecular-weight
isoforms of cyclin E in tumor issue, as measured by Western blot
assay, is a stronger predictor of poor survival than the currently
used predictors, as node-positive cancer, negative estrogen-receptor
status and late stage of disease (N Engl J Med 2002
Nov). |
This
fascinating finding may have important clinical implications,
but validation by prospective evaluation and much work is needed
before low-molecular-weight and total cyclin E can be considered
as relevant biomarkers which can be used into clinical practice. |
|
