Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer
DOI: 10.2122/gbc.2003.0022

May 2003

Breast-Conserving Surgery and Risk of Positive Margins in Breast Cancer
Although clear scientific evidence indicates that long-term survival is similar after breast conservation treatment or mastectomy, important questions have been raised:
(a) Does the trend and efforts towards a steadily increasing number of patients who treated with a less extensive surgery, by expanding the eligibility criteria, increase the risk of close or positive tumor margin?
(b) what is the effect of microscopic evidence of close or positive margin on the risk of IBTR
(c) should the women with a final close or positive resection margin undergone further surgery or a re-excision can be avoided by the availability of current effective adjuvant treatment -radiation, chemotherapy, tamoxifen-?
(d) Is local failure a true recurrence or a new primary ipsilateral breast tumor?
Data from randomized and nonrandomized studies allow us today to a scientific approach of these questions…

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Online ISSN : 1109 - 7647
   Print ISSN : 1109 - 7655

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last update: 22 May 2003