Current
best practices and rationalistic perspectives in causation-based
prevention, early detection and multidisciplinary treatment
of breast and gastric cancer
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COMMENTARY
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| Breast-Conserving
Surgery and Risk of Positive Margins in Breast Cancer |
| Abstract |
| Although
clear scientific evidence indicates that long-term survival is
similar after breast conservation treatment or mastectomy, important
questions have been raised: |
| (a)
Does the trend and efforts towards a steadily increasing number
of patients who treated with a less extensive surgery, by expanding
the eligibility criteria, increase the risk of close or positive
tumor margin? (b) what is the effect of microscopic evidence of close or positive margin on the risk of IBTR (c) should the women with a final close or positive resection margin undergone further surgery or a re-excision can be avoided by the availability of current effective adjuvant treatment -radiation, chemotherapy, tamoxifen-? (d) Is local failure a true recurrence or a new primary ipsilateral breast tumor? |
| Data
from randomized and nonrandomized studies allow us today to a
scientific approach of these questions… |
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