Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer



Professor Dimitrios H. Roukos, MD, PhD

Surgery & Precision Cancer Genome Medicine

Founding Director:
* Center for Biosystems and Genome Medicine
* Research & Innovation Commission
  Ioannina University, School of Medicine
Department of Surgery, University Hospital of Ioannina
Biomedical Research Foundation Academy of Athens (BRFAA)
* Systems Biology Unit
Publications: 231 papers in PubMed including 80 on clinical cancer genome analysis applying Next - Generation Sequencing, molecular interactions regulatory networks and nonlinear transcriptional biocircuits for clinical implications as well as 30 on Precision Medicine - Oncology.
Citations: 7800 including 13 papers each with > 100 citations; h-index 69 (Scopus)  

Phones: +30 265100-5572/-7423 (Univ.); +302651099-695/-769 (Univ. Hospital)

Biosketch profile  
Dr. D. Roukos has graduated from Athens University School of Medicine, Greece. He underwent specialist training in surgery at the J.W.Goethe-University Hospital in Frankfurt a.M., Germany where received his Doctorate ( He moved back to Greece and since 1990 works at the Ioannina University School of Medicine.

Stepwise progress from Clinical Research to Precision Oncology

1985 – 2000

LINEAR EXPERIMENTATION: Focus on traditional Surgical Oncology

2001 – Today

Translational single – gene research, prevention of hereditary cancer syndromes (Breast, Colorectal, Gastric); targeted therapy

2007 – Today

NONLINEAR EXPERIMENTATION: Molecular interaction networks, Genotype – Phenotype map

2008 – 2011

Genome-Wide Association Studies (GWAS)

2010 – Today

NEXT – GENERATION SEQUENCING (NGS): Conventional single biopsy – based approach

2014 – Today

Intrapatient Heterogeneity (IPH): Biomarkers and Drugs Discovery

  • Dynamics of comprehensive IPH (intratumor and circulating subclonal heterogeneity)
  • Linear transcription-based drugs targeting IPH
  • Innovative solutions towards future nonlinear transcription drugs targeting transcriptional biocircuits

National and International assessment, recognition and distinctions

2011 – Today

Evaluator in International Innovative Projects: In EU – EC (FP7; Horizon 2020), France, Italy Ministry of Universities and Research, Belgium.

2012– Today

Founding Director Center for Biosystems and Genome Network Medicine, Ioannina University, Ioannina, Greece.

2014 – Today

Affiliation in BRFAA, Athens, Greece.

2015 – Today

Scientific Director Research & Innovation Commission of Ioannina University, School of Medicine

Editorial Board Member in <20 Journals indexed in PubMed and ISI

Invited Speaker in International Meetings (<100)

Reviewer in International in multiple high-impact Journals including Nat Biotech, Nat Rev Genet, Nat Protocol, Lancet Oncology, Nat Rev Clin Oncol, …



ISSN : 1109 - 7647
   Print ISSN : 1109 - 7655


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last update: 23 February 2017