Gastric Breast Cancer Network Center

Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

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Dimitrios H. Roukos, MD, PhD

Emeritus Professor of Cancer Precision Medicine

	Founding Director: * Center for Biosystems and Genome Medicine

	Ioannina University, School of Medicine
	Biomedical Research Foundation Academy of Athens (BRFAA) * Systems Biology Unit

Publications: 257 papers in PubMed including 100 on clinical cancer genome analysis applying Next - Generation Sequencing, molecular interactions regulatory networks and nonlinear transcriptional biocircuits for clinical implications.
Cancer Precision Medicine: 7 in high-impact journals; and a total of 48 on Precision Medicine - Oncology.

Breakthrough Concepts

Citations: 10188 including 23 papers each with > 100 citations; h-index 79 (Scopus)

Updated July 22, 2021

Phones: +30 265100-5572/-7423 (Univ.); +302651099-695/-769 (Univ. Hospital)
E-mail: droukos@uoi.gr Website: www.gastricbreastcancer.com

SHORT CV

Biosketch profile

Papers in High-impact Journals: Cancer Precision Medicine
(Single, First or Corresponding author)

	PAPER	Impact Factor
1	Kyrochristos ID, Ziogas DE, Roukos DH. Dynamic genome and transcriptional network-based biomarkers and drugs: precision in breast cancer therapy. Med Res Rev. 2019 May;39(3):1205-1227.	12.944
2	Kyrochristos ID, Roukos DH. Comprehensive intra-individual genomic and transcriptional heterogeneity: Evidence-based Colorectal Cancer Precision Medicine. Cancer Treat Rev; 2019 Nov; 80:101894.	12.111
3	Roukos DH. Spatiotemporal diversification of intrapatient genomic clones and early drug development concepts realize the roadmap of precision cancer medicine. Drug discovery today. 2017;22(8):1148-1164.	7.851
4	Kyrochristos ID, Glantzounis GK, Goussia A, Eliades A, Achilleos A, Tsangaras K, Hadjidemetriou I, Elpidorou M, Ioannides M, Koumbaris G, Mitsis M, Patsalis P C, Roukos DH. Proof-of-concept pilot study on comprehensive spatiotemporal intra-patient heterogeneity for colorectal cancer with liver metastasis. medRxiv.	(Submitted)
5	Kyrochristos ID, Ziogas D, Roukos DH. Drug resistance: origins, evolution and characterization of genomic clones and the tumor ecosystem to optimize precise individualized therapy. Drug Discov Today. 2019 Apr 19. pii: S1359-6446(18)30398-2.	7.851
6	Ziogas DE, Kyrochristos ID, Roukos DH. Discovering novel valid biomarkers and drugs in patient-centric genomic trials: the new epoch of precision surgical oncology. Drug discovery today. 2018;23(11):1848-1872.	7.851
7	Roukos DH. Crossroad between linear and nonlinear transcription concepts in the discovery of next-generation sequencing systems-based anticancer therapies. Drug discovery today. 2016;21(4):663-673.	7.851
8	Kyrochristos ID, Ziogas DE, Goussia A, Glantzounis GK, Roukos DH. Bulk and Single-Cell Next-Generation Sequencing: Individualizing Treatment for Colorectal Cancer. Cancers (Basel). 2019 Nov 18;11(11):1809.	6.639

SELECTED CITATIONS IN HIGH-IMPACT JOURNALS

	PAPER	CITATION	Impact Factor
1	Roukos DH, Briasoulis E. Individualized preventive and therapeutic management of hereditary breast ovarian cancer syndrome. Nat Clin Pract Oncol. 2007 Oct;4(10):578-90. Review.	Zhang L, Jing D, Jiang N, et al. Transformable peptide nanoparticles arrest HER2 signalling and cause cancer cell death in vivo. Nat Nanotechnol. 2020 Jan 27.	33.407
2	Roukos DH, Murray S, Briasoulis E. Molecular Genetic Tools Shape a Roadmap Towards a More Accurate Prognostic Prediction and Personalized Management of Cancer. Cancer Biol Ther. 2007 Mar;6(3):308-12.	Ji X, Mukherjee S, Landi MT, et al. Protein-altering germline mutations implicate novel genes related to lung cancer development. Nat Commun. 2020 May 11;11(1):2220.	11.800
	Roukos DH. Genome-wide association studies: How predictable is a person's cancer risk? Expert Rev Anticanc Ther. 2009; 9: 389-392.
3	Roukos DH, et al. Approaching the dilemma between prophylactic bilateral mastectomy or oophorectomy for breast and ovarian cancer prevention in carriers of BRCA1 or BRCA2 mutations. Ann Surg Oncol. 2002 Dec;9(10):941-3.	Trusheim MR(1), Berndt ER, Douglas FL. Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers. Nat Rev Drug Discov. 2007 Apr;6(4):287-93.	57.618
4	Lianos GD, Alexiou GA, et al, Roukos DH. The role of heat shock proteins in cancer. Cancer Lett. 2015 May 1;360(2):114-8.	Nieto MA, Huang RY, et al. EMT: 2016. Cell. 2016 Jun 30;166(1):21-45.	36.216
5	Lianos GD, Alexiou GA, et al, Roukos DH. The role of heat shock proteins in cancer. Cancer Lett. 2015 May 1;360(2):114-8.	Manasanch EE, Orlowski RZ. Proteasome inhibitors in cancer therapy. Nat Rev Clin Oncol. 2017 Jul;14(7):417-433.	34.106
6	Kyrochristos ID, Ziogas DE, Roukos DH. Dynamic genome and transcriptional network-based biomarkers and drugs: precision in breast cancer therapy. Med Res Rev. 2019 May;39(3):1205-1227.	Andrei L(1), Kasas S(2), Ochoa Garrido I(3), et al. Advanced technological tools to study multidrug resistance in cancer. Drug Resist Updat. 2020 Jan;48:100658.	11.708
7	Roukos, D.H., Kappas, A.M. Perspectives in the treatment of gastric cancer. (2005) Nature Clinical Practice Oncology, 2 (2), pp. 98-107.	Lu Y, Lemon W, Liu PY, et al. A gene expression signature predicts survival of patients with stage I non-small cell lung cancer. PLoS Med. 2006 Dec;3(12):e467.	11.048

International Scientific Recognition as Leading Expert in Cancer Precision Medicine

Evaluator in:

International Projects

High-impact journals
Reviewer in high-impact journals (Nature Biotechnology, Nature Reviews Genetics, Lancet Oncology [13 reviews], Nature Reviews Clinical Oncology, Nature Communications, Nature Protocols) and multiple other journals.

Editorial Board Member (31)

Expertise in Precision Cancer Medicine

From a total > 100 papers on clinical cancer genome analysis applying NGS

48 on Precision Medicine - Oncology

Organizing Committee Member in International Meetings