Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer
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      Editor-in-Chief, D. Roukos, MD, PhD
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LAST UPDATE: February 20, 2018
    GBCNC Web Site       Associate Editor, J Ajani, MD Anderson, Houston, Texas
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GBC
TOP 10 PAPERS 2017
Personalized Structural Mutational Landscape
Conventional, single-biopsy NGS
  • Turajlic S, et al. Lancet Oncol 2017.
 
Breakthrough Genome analysis in time and space
  • Jamal-Hanjani M, et al. N Engl J Med 2017.
  • Joung JG, et al. Clin Cancer Res 2017.
  • Weiss GJ, et al. Clin Cancer Res 2017.
Intrapatient Comprehensive Dynamic Heterogeneity
 
Functional noncoding Mutations
  • Rheinbay E, et al. Nature 2017.
  • Feigin ME, et al. Nat Genet 2017.
Regulatory Networks
  • Barabasi, et al. Science 2017.
  • Anastasiadou et al. Nat Rev Cancer 2017.
GBC

Second issue: 2017

 
 
 
 
 
 
 
 
GBC

Past Issue

 
 
  Therapeutic intervention of Hepatic, Billiary and Pancreatic cancer genomes in time and space.
 
 
GBC

2016: TOP 10 Articles in Precision Cancer Medicine

 
 
 

* Role of non-coding sequence variants in cancer. Khurana E, et al. Nat Rev Genet. 2016

 
 
 
 
 

* Pancreatic cancer in 2015: Precision medicine in pancreatic cancer--fact or fiction? Seufferlein T, Mayerle J. Nat Rev Gastroenterol Hepatol. 2016

GBC

2015: Emergence of subclones – TUMOR HETEROGENEITY

 

2. Clonal evolution-single cell genome sequencing

3. Genome editing with CRISPR-Cas9

4. Subclonal diversification - multiregion sequencing

 
GBC

2014-2013

6. Genome network medicine: overcoming cancer therapeutic resistance

7. Non-invasive ctDNA sequencing

8. Selection adaptation and metastasis

 

9. Tumour heterogeneity in the clinic

GBC
PAST ISSUE
PERSPECTIVE
 

Improving survival with trastuzumab emtansine for HER2-positive breast cancer.

  Trametinib plus dabrafenib : Targeting RAS-MAPK pathway for BRAF V600-mutant melanoma.
 
EDITORIAL
 
 
 
NEWS & VIEWS
  Tyrosine kinase inhibitors expand indications for surgical resection of advanced GIST.
 
  Advances and limitations with multimodal treatment of Colorectal cancer liver metastases.
Ιατρική Ακριβείας του Καρκίνου
Spatiotemporal diversification of intrapatient genomic clones and early drug development concepts realize the roadmap of precision cancer medicine. Roukos D. Drug Discov Today. 2017 Aug;22(8):1148-1164.
Ολοκληρωμένη δυναμική ανίχνευση και στόχευση του συνόλου των γονιδιακών μεταλλαγών στο χώρο και στο χρόνο.
Crossroad between linear and nonlinear transcription concepts in the discovery of next-generation sequencing systems-based anticancer therapies. Roukos D. Drug Discov Today. 2016 Apr;21(4):663-73.
Σύγκριση των διαθέσιμων και νέων στοχευμένων φαρμάκων απλής γραμμικής μεταγραφής με μελλοντικά καινοτόμα φάρμακα επόμενης γενιάς που στοχεύουν σε δυναμικά μη γραμμικά μεταγραφικά δίκτυα.
International Conferences 2018
Organizing Committee: DH Roukos
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Dublin, June 11-13,
2nd Edition of International Conferences on Clinical Oncology and Molecular Diagnostics
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GENOMIC NETWORK MEDICINE

BREAST CANCER
GENOME OUTLOOK

Online ISSN : 1109 - 7647
Print ISSN : 1109 - 7655 ..

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last update: 20 February 2018